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Peruvian Journal of Neurosurgery

Prognostic factors in the survival of patients operated of astrocytoma grade II

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Introduction: Astrocytoma are the most common tumors of the CNS and constitute 40 to 50% of all brain tumors. Survival depends on several clinical factors and treatment, and the actual survival of patients operated on astrocytoma grade II in our region is unknown, so the objective of the present study was to know the survival of patients operated on astrocytoma grade II as well as determine What is the impact of pre-surgical and post-surgical prognostic factors on the survival of patients with grade II astrocytoma that were operated at the Guillermo Almenara Hospital between 2003 and 2009.
Methods: A retrospective, observational and longitudinal study of 38 patients operated on astrocytoma grade II at the Guillermo Almenara Hospital between 2003 and 2009. The data was collected from medical records, operative reports and telephone interviews. The patients were classified according to the histological type of astrocytoma and the variables were analyzed: Group of prognostic risk, type of treatment and extension of the surgery. The SPSS 15.0 was used for the analysis.
Results: Of a total of 124 patients with astrocytoma, 30% (38/124) had a grade II astrocytoma, with an average survival of 56.7 months. According to the clinical prognosis group, survival of the low, medium and high-risk groups was 74.8, 46.0 and 31 months respectively. Regarding the type of treatment, the group with the highest survival was radiotherapy + surgery (66.2 months), followed by surgery alone (44.8 months) and the shortest survival time was radiotherapy alone (37.6 months). The longest survival was the total resection group (68.7 months), followed by the single biopsy (39.1 months) and the shortest group survived the partial resection (21.0 months).
Conclusions: Survival of patients operated on Astrocytoma grade II in our hospital is 56.7 months, with the factors of better prognosis being the "low risk" group and the total resection. Its classification into prognostic risk groups based on pre-surgical clinical data helps us predict survival before surgery.
     Keywords: Astrocytoma, Prognosis, Brain Neoplasms, Survival, Risk factors (source: MeSH NLM)
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